There is abundant evidence that NAD+ plays an important role in aging, as it is involved in various biological functions and is a key regulator of stress resistance. Levels of NAD+ steadily decline with age or extreme excursion from sports, resulting in altered metabolism and increased disease susceptibility.

NAD+ (Nicotinamide Adenine Dinucleotide) is used to increase athletic performance. Increased mitochondrial ATP production for improvements in endurance, strength, and stamina have been observed. NAD is also used in higher doses for drug, alcohol, and addiction-related issues. NAD is used in lower doses for Anti-Aging and depression benefits. NAD Therapy has many benefits, these are only some of the more common uses.

Additional Benefits of NAD+ May Include:

  • Anti Aging by protecting telomeres
  • Clearing brain fog
  • Mental clarity
  • Metabolic function
  • Memory, Concentration, Mental Clarity
  • Supports addictive recovery
  • Superior immune support
  • Restores cellular production of energy (ATP)
  • Better sleep quality
  • Improvement in athletic performance & recovery

Frequency: Varies per person depending on assessed condition.


It’s important to note that IV therapy is the most beneficial method of replenishing your body’s NAD+ levels. Store-bought supplements are not an effective way of receiving this powerful coenzyme’s benefits because your body’s digestive system must break them down. IV Therapy bypasses your G.I tract and 100% NAD+ absorption begins immediately!


Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals, 2020

“NR supplementation increased NAD(P)H levels, decreased oxidative stress, and improved physical performance”

NAD-biosynthetic pathways regulate innate immunity, 2019.

“Recent studies indicate that macrophages utilize NAD+-biosynthetic pathways to control inflammation and cell survival during the immune response and aging.”

I Got a $600 Brain ‘Reboot’ and It Changed My World

NAD+ therapy can supposedly increase your energy, focus, and metabolism, improve your cardiovascular health, and help you detox from alcohol and drugs. All this, of course, sounds incredibly unlikely—so I thought I’d see for myself.

IV NAD plus amino acid outcomes, 2017, FDA

“Has been used since the late 1960s in intravenous form to significantly lessen withdrawal from a variety of drugs and alcohol”

Frequently Asked NAD+ Questions

What is NAD+?

NAD+ is a coenzyme found in all living cells. It’s responsible for transferring electrons and hydrogen in the Krebs cycle, making it a vital component for producing all of the energy your body uses. It’s involved in over 100 metabolic processes and is considered one of the most essential building blocks for life. Unfortunately, NAD+ levels decrease as you age and in response to psychological illnesses. This negatively impacts your health in many ways. Boosting your NAD+ can help restore your natural and healthy levels, enhancing your physical and mental wellbeing.

What To Expect During an NAD+ Infusion:

NAD+ is one of our favorite DRIP HAWAII  IV therapies because it has been amazing in helping our patients heal. It really is a “miracle molecule”, providing energy to the cells and stimulating cellular repair mechanisms. When given through an IV, 100% of the NAD+ is delivered right into your cells for the mitochondria to utilize. (Also bypassing the intestines for best absorption.) 

How are NAD+ infusions different from NAD+ supplements?

Raising your NAD+ levels through supplements isn’t as effective as through an infusion. Digestion is a problem for NAD+ because the substance is hard for the stomach to break down, making it less bioavailable. By bypassing the intestinal tract, the body is able to fully take in and utilize the NAD+ being administered. 

What has NAD+ infusion therapy been most famous for treating ?

NAD+ infusion therapy promotes healthier aging, performance and can help several mental illnesses, including substance abuse disorders, mood disorders, anxiety, and PTSD. It can also help with Lyme disease due to its ability to aid enzymatic functions.

How does NAD+ help with mental illnesses?

NAD+ is necessary for optimal mental health and recovery. NAD+ protects your neurons from damage and improves your cognitive function and mental clarity. It also combats stress, fatigue, exhaustion, and a lack of motivation.

How does NAD+ help with Athletic Performance?

From mitochondria ATP production that follows an NAD+ infusion, there have been improvements seen in athletes in reference to endurance, strength, stamina, recovery and overall athletic performance.

How does NAD+ help with aging?

As we age, NAD+ levels decrease within our bodies. In fact, by the time you are  50, you have about half the level of NAD+ that you had at age 20. Unhealthy lifestyle habits such as overeating, eating high-fat, inflammatory foods, regularly consuming alcohol, and experiencing prolonged periods of stress can actually accelerate the aging process already in young adults and deplete your NAD+ stores.  NAD+ through IV allows our bodies to get 100% absorption which helps us immediately improve mental clarity and conjunction, increase energy, and begin cellular repair. 

How does NAD help with addiction?
  1. It flushes out all of the drugs that are still in the user’s system.
  2. It reduces withdrawal effects, which can be extremely difficult and uncomfortable to tolerate during the detox process.
  3. It curbs the cravings for alcohol and Opioids and lessens the pain of withdrawal, making recovery easier physically and mentally.
  4. It allows the body to produce energy more naturally, without a crash or jitters like caffeine and sugar or the negative effects that come with other substances.
Is NAD+ Infusion Therapy safe?

NAD+ infusion therapy is a very safe treatment option as long as you are receiving your IV drip from a medical professional. NAS+ is a natural substance used in the body and is readily incorporated.

Do I need a referral?

You do not need a referral as we have a physician/medical director on staff. In regards to addiction or Psychological Disorders, we can help refer you to a specialized qualified Health Care professional to help you create a long-term plan to best utilize NAD+ for your specific needs.

Can I eat and/or drink prior to my infusion?

You can eat and drink before your infusion, we encourage avoiding over-processed/ junk food. 

Are there any possible side effects?

During the infusion, NAD+ can cause side effects such as nausea, brain fog, cramping, and muscle fatigue. However, these can often be relieved by slowing the IV drip. Never hesitate to let your nurse know how you feel. 

Can I drive home afterward?

Yes. There aren’t any lasting amnesiac or psychoactive effects of the infusion, so it’s safe to drive home afterward.

What are some signs that you may benefit from NAD+?

As we age, levels of NAD+ decline, so by the age of 50, we have lost 50% of our NAD+. This loss is accelerated when there is stress, inflammation or toxicant exposure. The mitochondria supply energy to every cell in your body, so if you are feeling fatigued, have brain fog, digestive issues, extreme fatigue or soreness after exercise, it may mean your mitochondria are struggling and could use the support of NAD+. NAD+ can also be helpful for sleep disorders, anxiety, chronic pain, and traumatic brain injuries.

Why are NAD+ infusions so unique?

Some IV vitamins or antioxidants can be given via a slow, gentle push over a few minutes, whereas others must be given over a longer period of time. Generally, these rates are universal for most people. However, with NAD+, the rate of the infusion is patient-specific. If NAD+ is pushed too quickly, patients may experience an uncomfortable sensation in their chests, abdomens, heads, or muscles. Some feel anxious or feel warmth come over their body. Once the IV is slowed down, these sensations resolve in a few seconds. 

How often should I get an NAD+ infusion?

As with any IV therapy, the frequency of treatments is dependent on the patient’s underlying medical condition or wellness goals. For Anti-aging & Neurodegenerative wellness, daily doses (or at least every other day) of 250mg-500mg are given for 4-5 days ( or treatments).  When treating drug and alcohol addiction, daily doses of 800-1500 mg are given for 7-15 days in a row. Back-to-back doses of NAD+ can be helpful to replete the body but are not necessary for everyone. For most patients who have severe fatigue, DRIP HAWAII recommends 1-2 times per week until they feel their energy return and then monthly as needed. For anti-aging, neurodegenerative, or general health maintenance, monthly or bi-weekly doses of NAD+ should be sufficient as long as you aren’t doing things that will deplete it. 

What can deplete NAD?

Research has shown that too much direct sunlight exposure can deplete the body of NAD+ levels. This is because our body uses NAD+ to repair cells that get damaged as a result of direct UV rays exposure from the sunlight.

Numerous studies have also shown that NAD levels decrease with aging and under poor nutrient conditions, such as obesity. Additionally, a decline in NAD levels is closely related to the development of various metabolic disorders, including diabetes and fatty liver disease

NAD+ levels are markedly reduced when blood alcohol levels are high during binge drinking. Excessive use of drugs and alcohol will also deplete the body's natural stores of NAD+.